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IIb cytoplasmic tail also can communicate with signaling proteins, including the calcium- and integrin-binding protein and also the serine/threonine protein phosphatase PP1 (Vijayan et al.
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These alterations paralleled raises in platelet attachment and spreading on to fibrinogen resulting from Improved integrin α
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3 lets talin binding in nonstimulated conditions. The improved talin binding probable improves the likelihood of Src associations and phosphorylation, thus enhancing platelet activation downstream of fibrinogen binding.
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